✍🏽 Welcome to Landon’s Loop: your go-to weekly read on Chicago’s innovation economy.
In this week’s newsletter #103:
- Why Illinois is home to two national labs
- Chicago sets a Q1 funding record
- A Drive-backed AI agent startup is looking for design partners
- The top tech events happening this week in the city
Illinois is one of the few states to have multiple US Department of Energy national labs: Argonne and Fermilab.
The only other states that have more than two are California, New Mexico, and Tennessee.
Our two labs are powerhouses of discovery with deep roots in American scientific progress. Both of our labs has a distinct origin story and mission, and they’ve helped shape major breakthroughs in energy, computing, and particle physics.
Let’s dive into the history behind Argonne and Fermi:
Established in 1946, Argonne evolved from the University of Chicago's work on the Manhattan Project. It was designated as the first national laboratory in the United States and has since become a multidisciplinary research center.
Argonne focuses on areas like energy storage, renewable energy, environmental sustainability, supercomputing, and national security.
Argonne researchers have developed advanced battery technologies, including lithium-rich nickel-manganese-cobalt cathodes, which have significantly improved the performance and reliability of lithium-ion batteries.
Founded in 1967, Fermilab is dedicated to high-energy particle physics. This laboratory has been instrumental in advancing our understanding of fundamental particles and forces.
In 1995, scientists at Fermilab announced the discovery of the top quark, the sixth and final quark predicted by the Standard Model of particle physics.
Beyond its scientific endeavors, Fermilab has a herd of American bison, established in 1969 by the lab's first director, Robert Wilson, symbolizing the connection between the frontier of physics and the American frontier.
Argonne’s impact goes beyond energy: their researchers helped invent technology used in Gorilla Glass.
Fermilab had a rec basketball team for employees called “the Protons”
Fermilab successfully demonstrated a 44-kilometer quantum entanglement network which is an early step toward secure quantum communication across the US.
Argonne’s Aurora supercomputer is so powerful, it can perform more calculations in a single second than the entire human population could in 31 years.
Our national labs do more than push the boundaries of science. They anchor Illinois as a global innovation hub:
Attracting world-class researchers
Driving billions in federal R&D funding
Seeding startups and cutting-edge tech
In a world racing toward quantum computing, clean energy, and AI, Argonne and Fermilab keep Illinois at the center of the map.
Breaking funding records: Chicago startups raised $900m in Q1’25. This is the highest amount since 2022 (and that’s just what’s been announced).
Despite higher funding totals, deal count is down from 2022. As the chart shows, $900M was invested across just 50 deals suggesting investors are placing more intentional, concentrated bets.
Founded by a UChicago grad, Autoplay is building AI agents that help users navigate software in real time. To make that possible, Autoplay built an AI engine that analyzes session replays to reveal where users struggle and why. 👇🏽
With Autoplay, you can power:
Context-aware co-pilots and chatbots
Smarter product tours
In-app agents that feel truly helpful
We’re looking for 3 more design partners to join us for April to help guide our roadmap. if interested feel free to book a time here.
Wednesday
AgeTech Chicago Meetup
Thursday
Chicago CoS Meetup
Thursday
Intercollegiate Demo Day
Student founders from across the Midwest are heading to Drive Capital this Friday for our first Intercollegiate Demo Day.
Archna & Jori's Product Leaders Breakfast
Friday
Comic Strips & Science Bits
Saturday
BuildIllinois Summit
Saturday
EdTech TechWalk
Sunday
Who’s building 2FA for AI agents?
As agents start logging into our platforms, querying APIs, and taking actions on our behalf, we’re going to need two-factor auth built for machines.
— Landon (@landon20s)
10:05 PM • Apr 4, 2025